Joint health facts

"Pain is the most important determinant of disability in patients with osteoarthritis"

"Incidence of osteoarthritis is higher among women than men among all age groups"

"The prevalence of osteoarthritis increases indefinitely with age, because the condition is not reversible."

Source: Bulletin of the World Health Organization – 2003

Pycnogenol® French maritime pine bark extract for joint health

Why it is important to keep healthy joints?

Our joints are subject to wear and tear and with increasing age the lining of joints - the "cushioning cartilage" - gradually degenerates. When cartilage has reached a significant abrasion, the articular tissue will be affected and this tissue trauma initiates a local inflammation. The consequence is a reduced flexibility of joints and pain which, left untreated, may reach excruciating levels.

More mobility, more flexibility, less pain, less drug.

In various studies, Pycnogenol® French maritime pine bark extract demonstrated its ability to promote joint mobility and flexibility and naturally relieve the aching. It was also shown that after supplementing with Pycnogenol®, joints were more flexible and less medication was required. In addition Pycnogenol® has been found to lower inflammatory markers of joint soreness.

How Pycnogenol® potently inhibits inflammation in arthritis and lowers inflammatory markers in osteoarthritis?

Consumption of Pycnogenol® was shown to limit the activation of the pro-inflammatory «master switch» NF-kB by 15.8%. This «master switch» commands the mobilization of all proinflammatory molecules, which play a destructive role in arthritis.

As a consequence, Pycnogenol® consumers generate less matrix metalloproteinase (MMP) enzymes, which are responsible for degenerating cartilage collagen in osteoarthritis. In addition, Pycnogenol® consumption was found to naturally inhibit generation of COX-2 enzymes during inflammation in humans, thus providing a significant contribution for lowering joint pain.

Pycnogenol potently inhibits inflammation in arthritis

Pycnogenol® lowers inflammatory markers CRP in osteoarthritis

Pycnogenol® was also demonstrated to significantly lower the inflammatory marker C-reactive protein (CRP) by 72% and reactive oxygen species (ROS) by 30%.

This finding suggests that the anti-inflammatory activity of Pycnogenol® is effective in individuals suffering from arthritic joints.

Horphag Research supplies Pycnogenol® as a raw material to companies that produce a variety of Pycnogenol®-containing products. Horphag Research does not make any claims regarding the use of these finished products and each manufacturer is responsible for ensuring that the claims made for and use of its products comply with the regulatory requirement of the locations in which it markets its products.