Pycnogenol® stimulates Human Growth Hormone (HGH) secretion in vitro thousand times more effectively than other natural compounds. Treatment with HGH increases muscle mass and decreases fat mass.
Buz'Zard, A.R., Peng, Q. and Lau, B.H.S.(2002)Kyolic and Pycnogenol® increase human growth hormone secretion in genetically-engineered keratinocytes.Growth hormone & IGF Research, 12: 34-40