GENEVA, Switzerland – According to a new peer-reviewed study published in the International Journal of Angiology, Pycnogenol® (pic-noj-en-all), a standardized natural plant extract from French maritime pine tree bark, may significantly improve the appearance, swelling and discomfort of pregnancy-induced varicose veins and spider vein clusters. Roughly 30 percent of women, post-pregnancy suffer from enlarged veins, which can be unattractive, painful and may lead to a chronic vein condition, blood clots and ulcers if veins do not return to healthy function. Pycnogenol® is available in more than 700 dietary supplements and multi-vitamins worldwide.
“Because some varicose and spider veins may improve on their own after a year or so post-pregnancy, standard treatment is to simply wear compression stockings, which is met with low compliance because patients often find them uncomfortable,” said Dr. Steven Lamm, a physician and nutritional medicine expert. “This study shows that Pycnogenol® can significantly reduce the visibility of veins, swelling and pain post-pregnancy and improve blood flow in a fraction of the time as it takes when treated with compression stockings alone.”
The open registry study, conducted at Chieti-Pescara University in Italy, included 133 women. All participants were recommended to wear compression stockings, as is the standard treatment, and the Pycnogenol® group consisted of 64 women who elected to take the extract 100mg/daily (50mg two times a day) in addition to wearing compression stockings.
Over 6 months, Pycnogenol® was shown to:
· Significantly reduce the number of varicose veins as compared to the control group
· Significantly decrease visible clusters of spider veins; the number did not significantly change in the control group
· Significantly reduce leg cramps as compared to control (4.6% with Pycnogenol®; 12.5% in control group)
· Significantly decrease minor pain and discomfort on prolonged standing
· Significantly reduce the number of points of major and minor venous incompetence
· Reduce swelling: after 6 months, only one Pycnogenol® patient reported swelling as compared to more than 13% in the control group
· Significantly decrease patient requests for additional treatment, such as chemical injections (sclerotherapy) or minor surgery as compared to the control group
Additionally, women in the Pycnogenol® group reported significantly higher satisfaction with the treatment and near perfect (96%) compliance; the control group registered less than 50 percent compliance with treatment.
“This study builds upon decades of research that shows Pycnogenol® to be a safe, effective, natural solution for venous insufficiency and the associated problems, said Dr. Gianni Belcaro, lead researcher of the study. “Pycnogenol® has been found to seal capillaries and stop the outflow of blood into tissue that causes swelling. It supports the production of endothelial nitric oxide to improve blood vessel function and blood flow.”
The women included in the study had each developed varicose and spider veins during their second pregnancy and began treatment within four to eight weeks after giving birth or after conclusion of breastfeeding and without interference of hormonal treatments. All women reported good vein health in advance of their second pregnancy.
Results were reported using a number of metrics: visual recording of number and length of varicose veins and spider vein clusters; a visual analog line scale to measure heavier legs, pain on prolonged standing, restless legs and bruises; ultrasound imaging to record points of major and minor venous incompetence and clinically-reported need for additional actions such as chemical injections, surgery or other medical treatment.
After 12 months, 98 women (56 in the Pycnogenol® group and 42 in the control group) were again evaluated without statistically significant changes occurring between six months and 12 months. Participants will be evaluated again at two years of treatment.
“This study confirms the findings of prior studies that have shown Pycnogenol® effective in strengthening capillary walls making them more resistant against pressure which consequently lowers the release of fluids into tissues. Pycnogenol® has been shown to exert a direct effect on the vein wall. It increases vein tonicity by improving vein resistance and vein elasticity. The extract reduces acute venous swelling and improves venous insufficiency,” said Dr. Lamm.
To review the clinical research and additional information on Pycnogenol® visit www.Pycnogenol.com.
About Pycnogenol®
Pycnogenol®is a natural plant extract originating from the bark of the maritime pine that grows along the coast of southwest France and is found to contain a unique combination of procyanidins, bioflavonoids and phenolic acids, which offer extensive natural health benefits. The extract has been widely studied for the past 40 years and has more than 340 published studies and review articles ensuring safety and efficacy as an ingredient. Today, Pycnogenol® is available in more than 700 dietary supplements, multi-vitamins and health products worldwide. For more information, visit www.pycnogenol.com.
About Horphag Research
Horphag Research Ltd. is the exclusive worldwide supplier of Pycnogenol® (pic-noj-en-all) brand French maritime pine bark extract. Pycnogenol® is a registered trademark of Horphag Research Ltd. For its patented ingredient, Pycnogenol®, Horphag Research has been awarded the Frost & Sullivan Excellence in Research Award, Nutraceutical Business & Technology Safety & Quality Award, SupplySide West Scientific Excellence Award and The American Botanical Council’s Tyler Research Award. For more information about Pycnogenol® visit www.pycnogenol.com