Clinical Dosage Calculator

Clinical Dosage Calculator for Finished Product Formulators

Select an Application

Antioxidant
Cardiovascular (blood pressure)
Cardiovascular (blood lipids)
Cardiovascular (blood microcirculation, endothelial function, vascular health)
Cardiovascular (platelet function, DVT, CVI, thrombosis, post-thrombotic syndrome)
Cognitive function (ADHD, mental performance in students and young professionals)
Cognitive function (memory, mood, mental performance and concentration)
Diabetes (metabolic syndrome, diabetic retinopathy, erectile function, kidney function)
Eye Health (intra-ocular pressure, retinal vein thrombosis, diabetic and other vascular retinopathies)
Healthy Aging (cognitive function, cardiovascular, menopause, muscle loss, joint, skin and beauty)
Immunology (common cold, lupus vasculitis)
Joint Health (joint mobility, arthritis, osteoarthritis)
Men's health (prostate, erectile function, fertility, muscle function, cardiovascular)
Oral Health (gum bleeding, plaque formation, dry mouth, oral malodor, oral mucositis)
Respiratory Health (asthma, hay fever, common cold)
Skin Care - Oral (hydration, elasticity, hyperpigmentation, melasma, pollution, photo-aging, psoriasis)
Skin Care - Topical (acne, wound healing, photo-aging)
Sports (endurance, performance, recovery, cramps, muscle loss)
Travel Health (DVT, jetlag, leg swelling, edema)
Venous Health (CVI, DVT, varicose veins, hemorrhoids, spider veins)
Women's Health (menopausal symptoms)
Women's health (menstrual discomfort)
 
Specific applications
Tinnitus and Menière's
Urinary tract
Restless legs
Raynaud
Vascular health (Pycno®Centella)

Antioxidant

Daily Dosage Range in mg

30-200

Belcaro, G., et al. (2021). Gazzetta Medica Italiana - Archivio per le Scienze Mediche 180(6): 289-294.
Belcaro, G., et al. (2015). J Neurosurg Sci 59(4): 437-446.
Muchova, J., et al. (2014). Free Radic Biol Med 75 Suppl 1(72): S42.
Belcaro, G., et al. (2013). Minerva Med 104(4): 439-446.
Enseleit, F., et al. (2012). Eur Heart J 33(13): 1589-1597.
Ryan, J., et al. (2008). J Psychopharmacol 22(5): 553-562.
Yang, H. M., et al. (2007). Acta Obstet Gynecol Scand 86(8): 978-985.
Chovanova, Z., et al. (2006). Free Radic Res 40(9): 1003-1010.
Dvorakova, M., et al. (2006). Redox Rep 11(4): 163-172.
Durackova, Z., et al. (2003). Nutr Res 23: 1189-1198.
Devaraj, S., et al. (2002). Lipids 37(10): 931-934.

Cardiovascular (blood pressure)

Daily Dosage Range in mg

50-200

Belcaro, G., et al. (2022). Minerva Med 113(2): 300-308.
Smetanka, A., et al. (2019). Physiol Int: 1-11.
Luzzi, R., et al. (2017). Minerva Ginecol 69(1): 29-34.
Belcaro, G., et al. (2013). Phytother Res 27: 1572-1578.
Stuard, S., et al. (2010). " Panminerva Med 52(2 Suppl. 1): 27-32
Cesarone, M. R., et al. (2010). " J. of cardiovascular pharmacology & Therapeutics 15(1): 41-46
Zibadi, S., et al. (2008). " Nutrition Research 28(5): 315-320
Yang, H. M., et al. (2007). " Acta Obstet Gynecol Scand 86(8): 978-985
Liu, X., et al. (2004). " Life Sci 74(7): 855-862
Hosseini, S., et al. (2001). " Nutr Res 21: 1251-1260. 

Cardiovascular (blood lipids)

Daily Dosage Range in mg

50-360

Szentesiova, Z., et al. (2022). Bratislava Medical Journal 123(04): 254-261.
Trebaticky, B., et al. (2019). Bratisl Lek Listy 120(12): 941-944.
Sedighiyan, M., et al. (2018). Acta Medica Iranica 56(3).
Luzzi, R., et al. (2017). Minerva Ginecol 69(1): 29-34.
Enseleit, F., et al. (2012). Eur Heart J 33(13): 1589-1597.
Belcaro, G., et al. (2013). " Phytother Res 27: 1572-1578.
Zibadi, S., et al. (2008). " Nutrition Research 28(5): 315-320.
Yang, H. M., et al. (2007). " Acta Obstet Gynecol Scand 86(8): 978-985
Durackova, Z., et al. (2003). " Nutr Res 23: 1189-1198.
Devaraj, S., et al. (2002). " Lipids 37(10): 931-934.
Koch, R. (2002). Phytother Res 16 Suppl 1: S1-5.

Cardiovascular (blood microcirculation, endothelial function, vascular health)

Daily Dosage Range in mg

60-200

Belcaro, G., et al. (2022). Minerva Med 113(2): 300-308.
Cesarone, M. R., et al. (2019). Minerva Cardioangiol 67(4): 280-287.
Hu S, B. G., Cornelli U, et al (2015). Int Angiol 34(1): 43-52.
Kohama, T. and M. Negami (2013). J Reprod Med 58(1-2): 39-46.
Enseleit, F., et al. (2012). Eur Heart J 33(13): 1589-1597.
Steigerwalt, R., et al. (2009). J Ocul Pharmacol Ther 25(6): 537-540.
Zibadi, S., et al. (2008). " Nutrition Research 28(5): 315-320.
Nishioka, K., et al. (2007). Hypertens Res 30(9): 775-780.
Cesarone, M. R., et al. (2006). Angiology 57(5): 569-576.
Belcaro, G., et al. (2006). Clin Appl Thromb Hemost 12(4): 440-444.
Cesarone, M. R., et al. (2006). Angiology 57(4): 431-436.
Belcaro, G., et al. (2006). Clin Appl Thromb Hemost 12(3): 318-323.
Liu, X., et al. (2004). " Life Sci 74(7): 855-862
Wang, S., et al. (1999). European Bulletin of Drug Research 7(2): 19-25.

Cardiovascular (platelet function, DVT, CVI, thrombosis, post-thrombotic syndrome)

Daily Dosage Range in mg

25-200

Cesarone, M. R., et al. (2019). Minerva Cardioangiol 67(4): 280-287.
Belcaro, G., et al. (2019). Minerva Cardioangiol 67(2): 109-114.
Belcaro, G., et al. (2018). Minerva Cardioangiol 66(2): 152-159.
Belcaro, G., et al. (2013). Minerva Med 104(4): 439-446.
Errichi, B. M., et al. (2011). " Panminerva Med 53(3 Suppl 1): 21-27.
Belcaro, G., et al. (2004). " Clin Appl Thromb Hemost 10(4): 373-377.
Wang, S., et al. (1999). " European Bulletin of Drug Research 7(2): 19-25.
Pütter, M., et al. (1999). Thromb Res 95(4): 155-161.
Araghi-Niknam, M., et al. (1999). Integrative Medicine 2(2/3).

Cognitive function (ADHD, mental performance in students and young professionals)

Daily Dosage Range in mg

20-150

Weyns, A.-S., et al. (2022). Journal of Functional Foods 97: 105247.
Weyns, A.-S., et al. (2022). Journal of Functional Foods 97: 105246.
Belcaro G., L. R., Dugall M., Ippolito E., Saggino A. (2014). J Neurosurg Sci 58: 239-248.
Luzzi, R., et al. (2011). PANMINERVA MEDICA 53(3): 75-82.
Dvorakova, M., et al. (2007). Nutr Neurosci 10(3-4): 151-157.
Dvorakova, M., et al. (2006). Redox Rep 11(4): 163-172.
Chovanova, Z., et al. (2006). Free Radic Res 40(9): 1003-1010.
Trebaticka, J., et al. (2006). Eur Child Adolesc Psychiatry 15(6): 329-335.

Cognitive function (memory, mood, mental performance and concentration)

Daily Dosage Range in mg

60-400

Belcaro, G., et al. (2022). J Neurosurg Sci 66(4): 371-377.
Donovan, E. K., et al. (2021). International Journal of Environmental Research and Public Health 18(5): 2468.
Cesarone, M. R., et al. (2020). J Neurosurg Sci 64(3): 258-262.
Hosoi, M., et al. (2018). J Neurosurg Sci 62(3): 279-284.
Belcaro G, D. M., Ippolito E, Hu S, Saggino A, Feragalli B (2015). J Neurosurg Sci 59: 437-446.
Kohama, T. and M. Negami (2013). J Reprod Med 58(1-2): 39-46.
Ryan, J., Croft, K., Wesnes, K and Stough, C (2008). J Psychopharmacol 22(5): 553-562.

Diabetes (metabolic syndrome, diabetic retinopathy, erectile function, kidney function)

Daily Dosage Range in mg

50-300

Belcaro, G., et al. (2019). Minerva Stomatol 68(6): 303-307.
Trebaticky, B., Muchova J, Ziaran S, Bujdak P, Breza J, Durackova Z (2019). Bratisl Med J 120(12): 941 – 944.
Hu S, B. G., Cornelli U, et al (2015). Int Angiol 34(1): 43-52.
Muchova, J., et al. (2014). Free Radic Biol Med 75 Suppl 1: S42.
Belcaro, G., et al. (2013). Phytother Res 27(10): 1572-1578.
Stuard, S. B. G., Cesarone, M.R., Ricci, A., Dugall, M., Cornelli, U., Gizzi, G. Pellegrini L, Rohdewald, P.J (2010). Panminerva Med 52(2): 27-32.
Steigerwalt, R., et al. (2009). J Ocul Pharmacol Ther 25(6): 537-540.
Zibadi, S., et al. (2008). Nutr Res 28(5): 315-320.
Cesarone, M. R., et al. (2006). Angiology 57(4): 431-436.
Belcaro, G., et al. (2006). Clin Appl Thromb Hemost 12(3): 318-323.
Liu, X., Wei, J., Tan, F., Zhou, S., Wurthwein, G. and Rohdewald, P (2004). Life Sci 75(21): 2505-2513.
Liu, X., Zhou, H.-J. and Rohdewald, P (2004). Diabetes Care 27(3): 839.
Devaraj, S., et al. (2002). Lipids 37(10): 931-934.
Hosseini S, L. J., Sepulveda RT, Rohdewald P, Watson RR (2001). Nutr Res 21(9): 1251-1260.

Eye Health (intra-ocular pressure, retinal vein thrombosis, diabetic and other vascular retinopathies)

Daily Dosage Range in mg

40-150

Manabe, K., et al. (2021). J Clin Biochem Nutr 68(1): 67-72.
Belcaro, G., et al. (2019). Minerva Cardioangiol 67(2): 109-114.
Rodriguez, P., et al. (2015). Panminerva Med 57(3): 121-125.
Steigerwalt, R., et al. (2009). J Ocul Pharmacol Ther 25(6): 537-540.
Spadea, L. and E. Balestrazzi (2001). Phytother Res 15(3): 219-223.

Healthy Aging (cognitive function, cardiovascular, menopause, muscle loss, joint, skin and beauty)

Daily Dosage Range in mg

30-200

Belcaro, G., et al. (2021). Gazzetta Medica Italiana - Archivio per le Scienze Mediche 180(6): 289-294.
Hosoi M, C. R., Belcaro G, et al (2018). J Sports Med Physical Fitness.
Hosoi, M., et al. (2018). J Neurosurg Sci 62(3): 279-284.
Luzzi, R., et al. (2017). Minerva Ginecol 69(1): 29-34.
Belcaro, G., et al. (2015). J Neurosurg Sci 59(4): 437-446.
Marini, A., et al. (2012). Skin Pharmacol Physiol 25: 86-92.
Kohama, T. and M. Negami (2013). J Reprod Med 58(1-2): 39-46.
Errichi, S., et al. (2011). Panminerva Med 53(3 Suppl 1): 65-70.
Ryan, J., et al. (2008). J Psychopharmacol 22(5): 553-562.
Farid, R., et al. (2007). Nutrition Research 27: 692-697.
Yang, H. M., et al. (2007). Acta Obstet Gynecol Scand 86(8): 978-985.

Immunology (common cold, lupus vasculitis)

Daily Dosage Range in mg

30-200

Belcaro, G., et al. (2021). Gazzetta Medica Italiana - Archivio per le Scienze Mediche 180(6): 289-294.
Cesarone, M. R., et al. (2020). Minerva Cardioangiol 68(2): 146-152.
Belcaro, G., et al. (2014). Panminerva Med 56(4): 301-308.
Belcaro, G., et al. (2013). Otorinolaringologia 63(3): 151-161.
Belcaro, G., et al. (2013). Minerva Med 104(4): 439-446.

Joint Health (joint mobility, arthritis, osteoarthritis)

Daily Dosage Range in mg

60-200

Feragalli, B., et al. (2019). Minerva Endocrinol 44(1): 97-101.
Jessberger, S., et al. (2017). BMC Complement Altern Med 17(1): 537.
Mülek, M., et al. (2017). Nutrients 9(5).
Kohama, T. and M. Negami (2013). J Reprod Med 58(1-2): 39-46.
Canali, R., et al. (2009). Int Immunopharmacol 9: 1145-1149.
Belcaro, G., et al. (2008). Redox Rep 13(6): 271-276.
Cisar, P., et al. (2008). Phytother Res 8: 1087-1092.
Belcaro, G., et al. (2008). Phytother Res 22(4): 518-523.
Farid, R., et al. (2007). Nutrition Research 27: 692-697.
Grimm, T., et al. (2006). J Inflamm (Lond) 3: 1.
Schäfer, A., et al. (2006). Biomed Pharmacother 60(1): 5-9.

Men's health (prostate, erectile function, fertility, muscle function, cardiovascular)

Daily Dosage Range in mg

50-200

Trebaticky, B., et al. (2019). Bratisl Lek Listy 120(12): 941-944.
Smetanka, A., et al. (2019). Physiol Int: 1-11.
Hosoi M, C. R., Belcaro G, et al (2018). J Sports Med Physical Fitness.
Ledda, A., et al. (2018). Minerva Med 109(4): 280-284.
Enseleit, F., et al. (2012). Eur Heart J 33(13): 1589-1597.
Durackova, Z., et al. (2003). Nutr Res 23: 1189-1198.
Roseff, S. J. (2002). J Reprod Med 47(10): 821-824.
Roseff, S. J. and O. Gulati (1999). Eur Bull Drug Res 7: 33-36.

Oral Health (gum bleeding, plaque formation, dry mouth, oral malodor, oral mucositis)

Daily Dosage Range in mg

20-150

Belcaro, G., et al. (2019). Minerva Stomatol 68(6): 303-307.
Watanabe, K., et al. (2018). J Nutr Sci Vitaminol (Tokyo) 64(3): 185-191.
Khurana, H., et al. (2013). Oral Dis 19(5): 456-464.
Kimbrough, C., et al. (2002). Phytomedicine 9(5): 410-413.

Respiratory Health (asthma, hay fever, common cold)

Daily Dosage Range in mg

40-150

Belcaro, G., et al. (2016). Minerva Biotecnologica 28(114-119).
Belcaro, G., et al. (2014). Panminerva Med 56(4): 301-308.
Belcaro, G., et al. (2013). Otorinolaringologia 63(3): 151-161.
Belcaro, G., et al. (2011). Panminerva Med 53(3 Suppl 1): 57-64.
Wilson, D., et al. (2010). Phytother Res 24(8): 1115-1119.
Lau, B. H., et al. (2004). J Asthma 41(8): 825-832.
Hosseini, S., et al. (2001). J Med Food 4(4): 201-209.

Skin Care - Oral (hydration, elasticity, hyperpigmentation, melasma, pollution, photo-aging, psoriasis)

Daily Dosage Range in mg

40-200

Zhao, H., et al. (2021). Skin Pharmacol Physiol: 1-11.
Grether-Beck, S., et al. (2016). Skin Pharmacol Physiol 29(1): 13-17.
Pinto, C., et al. (2015). Surg Cosmet Dermatol 7(3): 218-222.
Campos, V. (2014). J Am Acad Dermatol (P8471): AB19.
 Belcaro, G., et al. (2014). Panminerva Med 56(1): 41-48.
Marini, A., et al. (2012). Skin Pharmacol Physiol 25: 86-92.
Belcaro, G., et al. (2006). Clin Appl Thromb Hemost 12(3): 318-323.
Belcaro, G., et al. (2005). Angiology 56(6): 699-705.
Grimm, T., et al. (2006). J Inflamm (Lond) 3: 1.
Segger, D. and F. Schonlau (2004). J Dermatolog Treat 15(4): 222-226.
Ni, Z., et al. (2002). Phytother Res 16(6): 567-571.
Saliou, C., et al. (2001). Free Radic Biol Med 30(2): 154-160.

Skin Care - Topical (acne, wound healing, photo-aging)

Daily Dosage Range in mg

0.2-2 mg/ml (0.02-0.2%)

Kim, K.-Y. (2022). Journal of Digital Convergence 20(3): 487–495.
Pagano, C., et al. (2021). Pharmaceutics 13(3): 324.
Belcaro, G., et al. (2006). Clin Appl Thromb Hemost 12(3): 318-323.
Belcaro, G., et al. (2005). Angiology 56(6): 699-705.
Sime, S. and V. E. Reeve (2004). Photochem Photobiol 79(2): 193-198.

Sports (endurance, performance, recovery, cramps, muscle loss)

Daily Dosage Range in mg

60-200

Vinciguerra, G., et al. (2019). Panminerva Med 61(4): 457-463.
Aldret R, B. D. (2019). Journal of dietary supplements: 1-12.
Hosoi M, C. R., Belcaro G, et al (2018). J Sports Med Physical Fitness.
Vinciguerra, G., et al. (2013). J Sports Med Phys Fitness 53(6): 644-654.
Bentley, D. J., et al. (2012). Res Sports Med 20(1): 1-12.
Nishioka, K., et al. (2007). Hypertens Res 30(9): 775-780.
Vinciguerra, G., et al. (2006). Angiology 57(3): 331-339.
Pavlovic, P. (1999). European Bulletin of Drug Research 7(2): 26-29.

Travel Health (DVT, jetlag, leg swelling, edema)

Daily Dosage Range in mg

50-200

Belcaro, G., et al. (2018). Minerva Cardioangiol 66(2): 152-159.
Belcaro, G., et al. (2013). Minerva Med 104(4): 439-446.
Belcaro, G., et al. (2008). Minerva Cardioangiol 56((Suppl. 1 to issue N. 5) ): 3-9.
Cesarone, M. R., et al. (2005). Clin Appl Thromb Hemost 11(3): 289-294.
Belcaro, G., et al. (2004). Clin Appl Thromb Hemost 10(4): 373-377.
Pütter, M., et al. (1999). Thromb Res 95(4): 155-161.

Venous Health (CVI, DVT, varicose veins, hemorrhoids, spider veins)

Daily Dosage Range in mg

50-300

Cesarone, M. R., et al. (2019). Minerva Cardioangiol 67(4): 280-287.
Belcaro, G., et al. (2018). Minerva Cardioangiol 66(3): 238-245.
Belcaro, G., et al. (2018). Minerva Cardioangiol 66(2): 152-159.
Belcaro, G., et al. (2017). International Journal of Angiology 26: 12–19.
Belcaro, G., et al. (2017). Int J Angiol 26(3): 170-178.
Belcaro, G., et al. (2014). Minerva Ginecol 66(1): 77-84.
Belcaro, G., et al. (2013). Minerva Med 104(4): 439-446.
Belcaro, G., et al. (2010). Phytother Res 24(3): 438-444.
Cesarone, M. R., et al. (2010). Phytomedicine 17(11): 835-839.
Arcangeli, P. (2000). Fitoterapia 71: 236-244.
Pütter M, et al (1999). Thromb Res 95(4): 155–161.

Women's Health (menopausal symptoms)

Daily Dosage Range in mg

50-200

Smetanka, A., et al. (2019). Physiol Int: 1-11.
Luzzi, R., et al. (2017). Minerva Ginecol 69(1): 29-34.
Grether-Beck, S., et al. (2016). Skin Pharmacol Physiol 29(1): 13-17.
Kohama, T. and M. Negami (2013). J Reprod Med 58(1-2): 39-46.
Marini, A., et al. (2012). Skin Pharmacol Physiol 25: 86-92.
Errichi, S., et al. (2011). Panminerva Med 53(3 Suppl 1): 65-70.
Yang, H. M., et al. (2007). Acta Obstet Gynecol Scand 86(8): 978-985.

Women's health (menstrual discomfort)

Daily Dosage Range in mg

30-100

Maia, H., Jr., et al. (2014). Int J Womens Health 6: 1019-1022.
Maia, H., Jr., et al. (2014). Gynecol Obstet 4(2): 1-4.
Maia, H., Jr., et al. (2013). Int J Womens Health 6: 35-39.
Suzuki, N., et al. (2008). J Reprod Med 53(5): 338-346.
Kohama, T., et al. (2007). J Reprod Med 52(8): 703-708.
Kohama, T., et al. (2004). J Reprod Med 49(10): 828-832.
Kohama, T. and N. Suzuki (1999). Eur Bull Drug Res 7: 30-32.

Tinnitus and Menière's

Daily Dosage Range in mg

30-200

Belcaro, G., et al. (2021). Gazzetta Medica Italiana - Archivio per le Scienze Mediche 180(6): 289-294.
Luzzi, R., et al. (2014). Minerva Med 105(3): 245-254.
Grossi, M. G., et al. (2010). Panminerva Med 52(2 Suppl. 1): 63-67.

Urinary tract

Daily Dosage Range in mg

60-150

Ledda, A., et al. (2021). Evidence-Based Complementary and Alternative Medicine 2021: 9976299.
Cotellese, R., et al. (2021). Panminerva Med 63(3): 343-348.
Yagi, H., et al. (2017). J Tradit Complement Med 7(1): 117-120.

Restless legs

Daily Dosage Range in mg

150

Belcaro, G., et al. (2022). Panminerva Med 64(2): 253-258.

Raynaud

Daily Dosage Range in mg

100

Hu, S., et al. (2019). Minerva Cardioangiol 67(5): 392-398.

Vascular health (Pycno®Centella)

Daily Dosage Range in mg

50-150

Hu, S., et al. (2020). Minerva Cardioangiol 68(1): 22-26.
Belcaro, G., et al. (2020). Minerva Cardioangiol 68(1): 15-21.
Belcaro, G., et al. (2019). Minerva Cardioangiol 67(6): 450-455.
Belcaro, G., et al. (2017). Minerva Cardioangiol 65(1): 24-31.
Belcaro, G. and U. Cornelli (2017). Int J Angiol 26(2): 95-101.
Luzzi, R., et al. (2016). Minerva Cardioangiol 64(6): 603-609.
Belcaro, G., et al. (2014). Int Angiol 33(1): 20-26.
Belcaro, G., et al. (2014). Int Angiol 33(1): 20-26.